Hundreds of Biomarkers Uncovered to Combat Ageing Signs, paving the way for Anti-ageing cosmatics

Upam Bikash

Scientists identify for the first time numerous biomarkers that could be responsible for ageing signs in the skin, paving the way for advanced anti-ageing cosmetics and potential breakthroughs in the fight against wrinkles and sagging.

Hundreds of Biomarkers Uncovered to Combat Ageing Signs

In the past, scientists have explored epigenetic biomarkers as indicators of the biological age of organs like the skin. However, the key question remained unanswered – were these biomarkers the cause of ageing, or simply a consequence of the process? Raya Khanin and her team decided to tackle this challenge by analyzing two extensive sets of data.

The first dataset drew information from the UK Biobank study, which included over half a million participants. These individuals were asked whether they appeared younger, older, or their actual age, providing valuable insight into their perceived age. The researchers then linked this data to the participants' genetic variants to investigate if these variants might influence facial ageing.

The second dataset connected these genetic variants to epigenetic biomarkers found in nearly 7000 individuals. The team wanted to ensure they were uncovering epigenetic biomarkers that causally influenced the physical signs of ageing, not just observing a correlation between the two. To achieve this, they employed an analysis technique called Mendelian randomisation, which uses genetic variation as a proxy for the randomization of clinical trials.

The results were truly groundbreaking. The researchers discovered hundreds of epigenetic biomarkers, with around a quarter of them believed to be directly responsible for facial ageing. The remaining three-quarters were associated with either speeding up or slowing down the ageing process.

These identified biomarkers are believed to impact vital proteins involved in skin ageing, such as elastin and collagen. Elastin is responsible for skin elasticity, while collagen provides structure, strength, and further elasticity. Moreover, these biomarkers could also influence genes related to age-related skin pigmentation.

The implications of this discovery are enormous. Anti-ageing therapies could potentially target these biomarkers, leading to more effective and targeted cosmetic products. Furthermore, the findings could be instrumental in evaluating the efficacy of existing and future anti-ageing treatments.

While some experts, like Jesse Poganik at Harvard University, point out that the study partly relies on subjective data (participants self-reporting how others perceive their age), they also acknowledge the innovative approach of using Mendelian randomisation to pinpoint biomarkers driving the onset of ageing signs. This methodology opens the door to improved interventions in the quest for youthful and healthy skin.

In conclusion, the discovery of these hundreds of biomarkers offers a ray of hope for those seeking effective anti-ageing solutions. With the potential to develop cosmetics that specifically target the root causes of wrinkles and age-related skin sagging, the future of skincare looks more promising than ever before. Stay tuned as researchers continue their efforts to unlock the secrets of ageing, providing us with the tools to age gracefully and confidently.

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